The gas-fluid two-phase flow field and gas pressure drop in a rotating zigzag bed were simulated with computational fluid dynamics (CFD). A 2-D physical model was set up. The effects of rotational speed, number of baffles and gas flow rate on gas pressure drop and flow field were studied. The CFD model was validated by experimental results. The results show that the averaged relative error between experiments and calculation is less than 15%. The gas pressure drop obviously increases with increasing of the number of baffles and gas flow rate. The pressure drop also increases with increasing of the rotational speed, but not obviously. The pressure drop mainly exists in the interior of rotor, being 88%~97% of the total pressure drop, and 55%~73% of the rotor pressure drop is caused by the friction around the corner. There are backflow in the lower gaps of static baffles and dead zone in the upper gaps of rotating baffles, and 80% of the total velocity is tangential velocity which has peak value at the outer edge of rotor. The tangential velocity at rotor is greater than that at gas inlet. The radial velocity and axial velocity are different at different locations. The gas velocity change and pressure drop are caused by the rotational speed, number of baffles and gas flow rate.