The rule of removing alkali from the extracted vanadium residue was investigated under atmospheric pressure and constant temperature water bath through single factor experiment, and the parameters and the route of the ore blending and sintering process of the extracted vanadium residue after removal of alkali were determined. The experimental results showed that adding CaO in alkaline system, sodalited and cancrinite in the extracted vanadium residue is no longer stable solid phase, two Na+ was replaced by Ca2+ to produce a more insoluble calcium garnet phase, so that Na+ dissolved into the solution. Under the additive amount of NaOH was 20% of the extracted vanadium residue and the excess coefficient of CaO was 2, the content of Na2O in the extracted vanadium residue was decreased to 0.9%. Using the extracted vanadium residue after removal of alkali replaced of low vanadium high grade iron concentrate powder for ore blending and iron making, the added amount was about 20 kg/t, and the amount had no influence on the sintering parameters. And the sinter indexes of finished product were improved obviously after adding residue thanking for the low grade of SiO2 in the vanadium-titanium ore of Chengsteel Group Co., Ltd., and the drum index also improved by 0.6%.