Desulfurization ash was chemical modified by silane coupling agents Si69 and KH550, then environmentally friendly styrene butadiene rubber was prepared using chemical modified desulfurization ash replacing partial carbon black. The optimization model was established by uniform design combination with BP neural network to acquire parameter of optimal environmentally friendly styrene butadiene rubber. Optimal environmentally friendly styrene butadiene rubber was characterized. The results showed that the preparation parameters of optimal environmentally friendly styrene butadiene rubber were contents of silane coupling agents Si69 4.3wt% and KH550 3.8wt%, content of absolute ethyl alcohol 22.1wt%, stirring speed 705 r/min and reaction temperature 82℃. The mechanical properties of optimal environmentally friendly styrene butadiene rubber were tensile strength 19.64 MPa, tear strength 44.96 kN/m and Shore A hardness 66. The experimental results were good agreement with the predict results, relative error was 3.03%?2.65%.