Low solid loading bio-reaction system lead to high energy and water consumption, as well as environment pollution in fermentation industries, ing the development of high-solid bio-reaction system. High-solid bio-reaction system has the advantages of low energy consumption, less used water and environmentally-friendly. Additionally, high-solid loading leads to higher concentration of substrate and products which are benefit to reduce cost and realize the economical efficiency in production. However, many difficulties have existed in high-solid bio-reaction system apart form so many advantages. Therefore, it is of great mean to get knowledge about the characteristics and problem of high-solid bio-reaction system which will help to make the most use of its advantages. Taking enzymatic hydrolysis and fermentation of lignocellulose for an example, increasing solid loading leads to ‘solid effects’ and ‘water constraint’. Those phenomenon result in the formation of complex multi-phase system consisted by solid, liquid, gas and the microorganism. Mass transfer performance in this high-solid and multi-phases system is deficient, thus affecting lignocellulose conversion performance. Additionally, the changes of rheology characteristics in high-solid and multi-phases bio-reaction system caused by increasing solid loading make it inappropriate to apply traditional mechanical agitation which is based on shear force (i.e. shear force can results in activity loss of the enzyme and microorganism) to high-solid and multi-phases bio-reaction system, putting new requirements on agitation methods, design and amplification of bioreactor and process of high-solid and bio-reaction system. Based on several-years studies, the conception of high-solid and multi-phases bio-reaction engineering was proposed. Key factors which affect the reaction performance were analyzed from the perspective of solid matrix characteristic. Intensification method based on periodical normal force is innovated and periodic peristalsis high-solid and multi-phases bio-reaction system was developed with the expectation of providing theory and technical support for studying high-solid and multi-phases bio-reaction engineering.
Lan WANG Yang LIU Hongzhang CHEN
. High-solid and multi-phases bio-reaction engineering[J]. The Chinese Journal of Process Engineering, 2018
, 18(5)
: 918
-923
.
DOI: 10.12034/j.issn.1009-606X.218232
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