With the popularity of modernization and greening the concept of chemical industry, oxidation process, especially the new oxidation process, occupied an increasing proportion in the current process. However, most of the oxidation reactions were strong exothermic reactions, and the materials involved in the reactions were often unstable. In order to prevent the occurrence of reaction accidents, it was necessary to conduct a systematic study on the safety of reaction. A semi-intermittent dynamic reactor model with control condition was established by using process simulation method for liquid-phase oxidation. The structure, heat transfer setting and process control setting scheme of the reactor model were introduced. The epoxidation of propylene was simulated, the kinetic parameters and reactor parameters were set up. The reactor parameters were calculated by simulating the normal reaction process, demonstrating that the reaction was carried out under normal conditions. Based on the established model, the risk of multi-scene reaction under the conditions of closed insulation, cooling failure and cooling water control valve failure was simulated. The changes of temperature and pressure in the reactor and the composition of the material in the reactor were obtained, which provided data and technical support for making reasonable safety control measures in the follow-up work.