The pressure drop characteristics of an axial moving bed were investigated by varying the operating parameters including the superficial activation energy gas velocity, the particle circulation rate and the dust concentration in the inlet gas. The results showed that when the circulation rate of particles increased from 0 to 2.26 kg/(m2?s), the pressure drop of the equipment decreased slightly by 0.03 kPa. Besides, the influence of press cake in bed on the stability of pressure drop was studied under the operating condition of dust load. When the dust concentration in the inlet was low, the dust deposited in the moving bed could not form a stable filter cake structure, and the pressure drop fluctuation of the equipment was considerable. When the inlet gas dust concentration increased to 89.10 g/m3, the formation of filter cake in the moving bed tended to be stable, and the pressure drop operation of the equipment gradually became stable. Under dust load condition, when the equipment was in the fixed bed operation state, the static pressure drop increased rapidly with filtration, and increased with the increase of the dust concentration in the inlet gas, and the pressure drop increased faster. In addition, the pressure drop of the equipment reached a stable state around 500 s, at which time the pressure drop increased by about 0.10?0.14 kPa, and the fluctuation amplitude of the pressure drop after 500 s gradually decreased with the increase of dust concentration. Furthermore, when the superficial activation energy gas velocity was 0.126 m/s and the dust concentration was 89.10 g/m3, the process of press cake forming and damaging present a dynamic balance. After filtering for 500 s, the pressure drop stabled at 0.88 kPa. At the same time, the equipment had a high dust removal performance, and the dust collection efficiency of the equipment was more than 96%.