Selective reduction reaction (SCR) has become one of the most promising methods to reduce NOx emission for decades, in which catalysts play a key role to achieve good denitration (DeNOx) performance. V-based extruded honeycomb catalyst shows great advantages in the denitration process of power industry due to its high activity and excellent tolerant to SO2 and H2O, and the catalyst cost is gradually reduced with the further development of this technology. For medium/small boiler with flue gas below 300℃, however, much more expensive V has to be used to achieve high activity at low temperature, which significantly increases the catalyst cost for extruded honeycomb. Therefore, it is urgent to develop a low-cost catalyst with excellent low-temperature activity. In this work, a coated honeycomb catalyst was prepared by impregnating V–W–Ti catalyst slurry with blank clay honeycomb as an inexpensive support, and characterized by XRF, XRD, BET, SEM, etc. The results showed that the binder had a great influence on the DeNOx activity and strength of the catalyst for different kinds of dispersants, binders and reinforcing agents. Particularly, the coated honeycomb catalyst prepared by the addition of binder B3 had best DeNOx activity and strength. The prepared honeycomb catalyst with B3 binder had a dense coating on its surface to give it good strength. Moreover, the DeNOx activity increased with the increased content of catalyst coating. The coated honeycomb catalyst prepared at optimized parameters could reach 20.3% NO conversion rate for one honeycomb single-channel, which was much higher than the commercial extruded honeycomb catalyst (18.1% NO conversion rate, single-channel). Compared with extruded honeycomb, the catalyst cost used for coating honeycomb significantly reduced. In addition, the results of abrasion resistance test predicted that the prepared coated honeycomb catalyst may work stably for 128000 h in the flue gas from coking plant, which showed great industrial application prospects.