In the industrial application of ethylene pyrolysis tubular heating furnace, the fluid transferred from horizontal to rotary flow by adding twisted slices internals, which increased the tangential velocity and strengthened the flushing effect on the tube wall, so as to achieve the purpose of enhancing heat transfer. Based on the second generation of twisted slices, the structure was improved, and RNG k?ε turbulence model was used to simulate the flow details inside the furnace tube. The longitudinal vorticity structure, resistance coefficient, Nusselt number Nu, comprehensive heat transfer coefficient PEC and the coupling coordination between velocity vector field and temperature gradient field in different twisted slice structures were compared and analyzed. The results showed that the structure with "slit" openings along the wall can reduce the loss of flow resistance while increased the strength of fluid swirl. The resistance coefficient of twisted slices with opening structure of 7 mm length, 2 mm width and 2 mm interval was 93.75% of the first generation and 8.67% more than the second generation, but the comprehensive heat transfer coefficient was 1.56% higher than that of the second generation and 1.29 times of the smooth tube. It can be considered that the optimized structure improved the stability of longitudinal vortex structure as well as strengthened the coupling between flow and heat transfer. Besides, along the central opening of the slices, the resistance coefficient at the twisted slices increased, resulting in larger local losses.