The adsorption of bromide ions from the mother liquor produced during the process of mining potassium from rock-salt mines onto D301 anion exchange resin in a Perspex column was investigated. Relevant breakthrough curves were obtained, which would provide valuable information for the process design at a real scale. Experiments were carried out to study the effects of the initial adsorbate concentration, bed length, and flow rate. The bed capacities were found to increase with increasing initial adsorbate concentration and decreasing flow rate. When the initial Br? concentration increased from 1000 mg/L to 4000 mg/L, the adsorption capacity increased from 1.8 mg/mL to 6.4 mg/mL. The breakthrough time and the exhaust time increased with increasing bed length and decreasing flow rate, whereas they remained almost the same when changing the initial adsorbate concentration. Five adsorption models, including Bed Depth Service Time (BDST), Thomas, Yoon-Nelson, Wolborska and Modified dose response (MDR) were applied to predict the breakthrough curves and to determine the characteristic parameters of fixed-bed column. The MDR model was found to be the best fit to the experimental data. This study indicates that the D301 anion exchange resin can be used to extract bromide ions from mother liquors effectively in the competition with high concentrations of chloride ions.