Cooling law of high temperature glass in air-grid plays an important role in the stress of tempered glass, and there are many factors that affect the cooling law of glass. However, because glass moves fast in air-grid, it is very difficult to test the real-time temperature change of high-temperature glass. Moreover, the test of glass cooling for each influencing factor greatly increases the workload of workers. So the physical model of glass cooling in air-grid was established to numerically simulate the cooling law, and in order to verify the reliability of the model, the cooling law of high temperature glass had been tested in air-grid with infrared thermometers under the set parameters. After the high temperature glass entered into the air-grid, the glass temperature at different times presented a strip, which reflected the nonuniformity of glass cooling, but on the whole, the glass temperature gradually decreased with the quenching time, and the glass temperature decreased with quenching time in a negative index. The numerical simulation results were in good agreement with the test results. Then the physical model was applied to simulate the cooling law of high temperature glass with the effect of wind pressure, wind temperature, distance from nozzle to glass, speed out of the heating furnace, and round-trip speed in air-grid. The results showed that the glass temperature decreased exponentially with the wind cooling time. The greater the wind pressure was and the lower the wind temperature was, the faster the glass cooling was, that was, the wind pressure and the wind temperature had a significant influence on the cooling law of glass. Secondly, the distance of the nozzle to glass had a certain effect on the glass cooling, and the effect of speed out of the heating furnace, and round-trip speed in air-grid was not obvious. This study provided important theoretical basis for setting technological parameters of tempered glass production process.