Four factors including resin dosage, solution pH, methyl orange or Congo red concentration and adsorption time were selected to investigate the effects on the removal of methyl orange or Congo red adsorbed on MIEX resin using Box-Behnken response surface methods. According to the experimental results, the quadratic polynomial regression model was established to predict the removal of methyl orange or Congo red. Variance and significance were used to test the reliability of the regression equation. Based on the regression model, the operation parameters of the removal of methyl orange (Congo red) adsorbed on MIEX resin were optimized and the optimal conditions were obtained. Under the optimal conditions, the removal efficiency of methyl orange and Congo red on MIEX resin were 99.12% and 98.29%, respectively. The interaction between solution pH and resin dosage had a significant effect on the removal efficiency of methyl orange and Congo red. The saturated resin adsorbed methyl orange or Congo red were regenerated using NaCl solution, and the surface morphology of MIEX resin were characterized by field scanning electron microscopy. The results showed that the spent resin can be regenerated well with NaCl solution.