The leaching process and kinetics of African high silicon low grade copper cobalt ore in ammonia leaching system were studied. Firstly, the controllable variable method was used to systematically study the effects of leaching agent concentration, additive dosage, reaction temperature, reaction time and liquid/solid ratio on the leaching rate of copper and cobalt through single factor experiments. Secondly, the phase and chemical composition of high silicon low grade copper?cobalt ore and leaching residue were analyzed by X-ray diffraction (XRD), inductively coupled plasma (ICP) and scanning electron microscope-energy spectrum (SEM-EDS). The results showed that the leaching rate of copper and cobalt can reach 97.29% and 95.18% respectively, under the technological conditions of ammonium sulfate as leaching agent with the concentration of 300 g/L, reducing agent of 0.7 g, leaching temperature of 353 K, reaction time of 240 min and liquid/solid ratio of 6:1. Finally, by analyzing the kinetic model of copper extraction by high silicon low grade copper?cobalt ore ammonia leaching, the activation energy, reaction order of ammonium sulfate concentration and particle size are 76.06 kJ/mol, 1.50 and 0.25, respectively, indicating that it should follow the interface chemical reaction control, and the corresponding kinetic equation was established.