In order to solve the problem of air with liquid in the solution dehumidifier, a method of intermittent operation of the solution dehumidifier was proposed, which separated the air supply from the solution spray. The numerical model of dehumidifier was established, and the feasibility of the model was verified by comparing the experimental data and simulation data. Based on the model, the influence of operation parameters and design parameters of intermittent solution dehumidifier on dehumidification performance was studied and the operation effect of different air supply systems was simulated. The results showed that the static liquid holding capacity should be controlled in the range of 4.575~6.100 kg/kg and the packing height should be controlled in the range of 0.45~0.75 m, the intermittent operation method was more suitable to deal with the air with low temperature and high humidity (such as 20℃ and RH95%), which can solve the problem of traditional solution dehumidification with liquid. The dehumidification effect of the parallel staggered air supply system was the best, during the operation, the dehumidification rate was more than 5 g/kg, which can supply air continuously and meet the dehumidification demand.