In order to reveal the shear-dispersion performance of gas?liquid two-phase agitator, a double-layer agitator with six flat blade disk turbine on the upper layer and propeller blade on the lower layer was proposed and models of tilted shaft agitators with different angles (0°~30°) were established. Calculation and analysis of the hydraulic performance in a stirred tank were carried out by Reynolds average Navier-Stokes equation, RNG k?? turbulence model and VOF multiphase flow model. Unidirectional fluid-structure interaction was used to analyze the stress magnitude and distribution characteristics of tilted shaft agitator, and the material failure was checked based on the ANSYS Workbench platform. It was concluded that the inclined shaft improved the axial flow in the agitator, and the gas phase diffusion ability in the axial direction was enhanced; when the inclination angle was between 0°~30°, the time for the agitator to reach 95% gas content was significantly shorter than that at 0°, and the time required for 25° and 30° tilting shaft stirrers were shortened by 12.50% and 22.71%. At the same rotating speed, the shaft power increased with the increase of shaft tilt angle. The higher the rotation speed, the shorter the time for the agitator to reach the ideal gas content. The variation law of the mixing time with the shaft tilt angle under different rotation speeds was basically consistent. As the inclination angle increased, the equivalent stress and shaft power of the agitator increased. When the inclination angle was 30°, the stress at the dangerous section of the flat disk turbine agitator exceeded the range of safety stress, which was prone to fracture failure. When the inclination angle was 30°, the stress at the dangerous section of the straight blade disc turbine was higher than the allowable torsional stress of the blade by 8.7% which was beyond the safe stress range, and the blade was prone to fracture failure.