Sulforaphane is made into proliposomes to improve the stability of liposomes, while improving the water solubility and bioavailability of sulforaphane. Taking the encapsulation efficiency and particle size as indicators, the carrier materials, the type and amount of surfactants and the effects of lipid-drug ratios were investigated respectively. The optimal formulation of proliposome was optimized by response surface method. The stability of liposomes and proliposomes was investigated through room temperature stability experiments. The results showed that the optimal prescription was that the mass ratio of lipid phase to sulforaphane was 6.5:1, the mass ratio of NaCl to sulforaphane was 105:1, and the mass ratio of poloxamer-188 to sulforaphane was 1.5:1. The maximum average encapsulation rate was 77.43%, and the average particle size was 160.5 nm. Stability experiment results showed that when the drug retention rate was used as an indicator, liposomes and proliposomes had good stability within 60 days and a high retention rate of sulforaphane. When the encapsulation rate was used as an indicator, the liposome suspension produced precipitated, the encapsulation rate decreased, and the encapsulation rate of the proliposome did not decrease significantly within 60 days. This indicated that the proliposome can solve the oxidative deterioration of sulforaphane and the decrease of the encapsulation rate of the liposome due to precipitation, flocculation and other reasons. The proliposome has high encapsulation efficiency and simple preparation. It not only improves the stability of sulforaphane, but also improves the water solubility of sulforaphane and has broad application prospects.