Vanadium lead zinc ore contains a variety of valuable metals with high V grade and high economic value. In this work, vanadium and zinc were extracted from the mine by sulfuric acid leaching method, and the thermodynamics of the leaching process was analyzed. The effects of sulfuric acid concentration, liquid-solid ratio, leaching time, stirring rate and leaching temperature on the leaching rate of vanadium, lead and zinc were studied through conditional experiments. The results showed that the hydrolysis of V in the leaching solution and hydrolysis products containing V remained in the leaching residue at high pH and higher temperatures, which affected the leaching rate of V. The optimum leaching conditions were as follows: sulfuric acid concentration 200 g/L, liquid-solid ratio 3:1, leaching time 30 min, stirring rate 200 r/min and leaching temperature 30℃. Under the optimum conditions, the V leaching rate was 97.90%, the Zn leaching rate was 97.11%, the Fe leaching rate was less than 1%, and the Pb leaching rate was less than 0.01%. The results of kinetic analysis showed that the reaction rate of leaching process was controlled by diffusion process. In the acid leaching process, V and Zn entered the leaching solution, and Pb and Fe remained in the leaching residue. The resulting leaching solution can be separated by ion exchange or extraction. The leaching residue contained 0.41wt% vanadium, 0.61wt% zinc, 15.50wt% iron and 47.70wt% lead. The main components were PbSO₄ and FeO(OH), which can be returned to the pyrometallurgical lead smelting system.