Gas-liquid coalescence filtration is widely used in process industry. The wettability of fiber material is the key factor affecting the filtration performance of coalescing element. Based on the optical measurement method, the wettability difference of liquid on the surface of single triangular, trilobal and cruciform fiber was studied. The change process of liquid contact angle and volume was analyzed, and the influence of liquid type, fiber inclination angle and profiled degree on wettability was investigated. The results showed that with the decrease of liquid surface tension, the contact angle reduced and therefore the wettability enhanced. However, the volatility of liquid was easy to cause the actual contact angle to be greater than the theoretical one. The contact angle of triethylene glycol, dioctyl sebacate and silicone oil did not change with time. The contact angle of water and ethanol gradually decreased with time, and the decreasing rate of ethanol was greater due to the higher evaporation rate. The contact angle of liquid presented a "V" shape distribution with the inclination angle of the profiled fiber, that was, there was a minimum point (inclination angle of 30°) to make the fiber wettability reach the best. When the profiled degree of the fiber increased, the contact angle difference between different liquid decreased and the overall wettability improved, which indicated that the fiber with higher profiled degree should be selected as the material of prefilter layer or drainage layer.