Maleic anhydride grafted ethylene-octene copolymer (POE-g-MAH) and glycidyl methacrylate grafted ethylene-octene copolymer (POE-g-GMA) were introduced into the polylactic acid (PLA)/polypropylene (PP) blends to prepare different structures and performance blended materials (PLA/PP/POE-g-MAH, PLA/PP/POE-g-GMA). The effects of compatibilizers with different structures on the regulation behavior of interface state and performance of PLA/PP blends were investigated by the torque rheometer, DSC, SEM, flat rheometer and electronic universal testing machine, etc. The results showed that both POE-g-MAH and POE-g-GMA could improve the interface morphology of PLA and PP, but compared with POE-g-GMA, the interface catalytic efficiency of POE-g-MAH was higher, which could induce PLA and PP more compatible, and catalyzed the formation of micro cross-linking structure at the interface between PLA and PP, which enhance the interfacial interaction between PLA and PP, and finally improved the mechanical properties of the material. When 4wt% POE-g-MAH was introduced, the tensile strength of the PLA/PP/POE-g-MAH blend reached 29.7 MPa, and the elongation at break increased to 39.3%, which was 8 times higher than that of PLA/PP sample. Also, the impact strength of the samples enhanced with the increase of the content of POE-g-MAH, and when its addition amount was 6wt%, the impact strength of the material reached 30.1 kJ/m2, which had a good balance of rigidity and toughness.