The cryogenic ball valve is one of the indispensable fluid pipeline control devices in liquefied natural gas (LNG) receiving terminal. Its reliability directly affects the stability of the entire system, especially, when the ball valve has a serious valve seat seal leakage problem, which will seriously threaten the normal operation of industrial production and the safety of operators. In this work, based on the thermo-solid coupling method, the software of ANSYS Workbench was adopted to simulate the contact characteristics, including contact gap and contact pressure, of the lip seal of the cryogenic ball valve used in the LNG receiving station. Firstly, the distribution of temperature and Mises stress of lip seal under low-temperature conditions were analyzed. It was found that there were significant temperature differences in the lip seal, and the maximum temperature difference of the lip seal ring was 77℃. The temperature on the path from the inner lip seal ring to the outer lip seal ring decreased in order, which results in a significant increase of Mises stress. The maximum Mises stress reaches 204.92 MPa. Secondly, the contact characteristics of the lip seal under normal temperature and low-temperature conditions were analyzed. The results showed that the contact gap between the lip seal ring and the valve body and seat was unchanged, and the maximum contact pressure was evenly distributed along the circumferential direction under normal temperature conditions. While the contact gap of the lip seal increased and the contact pressure decreased under low-temperature conditions. The maximum contact gap reached -0.72 mm. Finally, the effects of different spring forced on the contact characteristics of the lip seal under low-temperature conditions were studied. It was found that the sealing performance of the lip seal could be improved to some extent by increasing the force. When the force of the spring was greater than 7000 N, the contact pressure between the lip seal ring and the valve body was greater than zero, and the precondition for sealing can be reached. This work has a certain reference value for the design and research of the seat seal of a cryogenic ball valve.