With the depletion of high-grade minerals, traditional pyrometallurgy with high cost and serious environmental contamination is no longer suitable for the sustainable development of the economy and society of China. Biohydrometallurgy is a bacterial-assisted leaching process to solubilize or expose the metals contained in different minerals, and the main role of the bacteria is to regenerate ferric ions and protons. Since the 1980s, biohydrometallurgy including heap bioleaching and tank bioleaching has been widely used for the recovery of metals such as copper and gold from low-grade and complex minerals because of its easy operation, low cost, and environmental advantages. Up to now, about 15% of the world's copper production can be attributed to the heap bioleaching of copper ore and about 5% of the world's gold production can be attributed to the biooxidation of refractory gold ore in continuous stirred tank reactors. However, the relatively slow reaction velocity of biohydrometallurgy is the main limitation to its further development. The application of biohydrometallurgy has been promoted remarkedly by the development of chemical engineering technology in history such as chemical reaction engineering and chemical separation technology. The process intensification of biohydrometallurgy based on chemical engineering technology is still one of the most important research interests in the future. Therefore, the research progress of chemical engineering technology in the process intensification of biohydrometallurgy was reviewed in this paper to help a better understanding. The influencing factors of efficiency in heap bioleaching and tank bioleaching were discussed mainly from an industrial point of view, and future research prospects were also put forward.