The vanadium-titanium magnetite ore is an important characteristic resource in Panxi area of China, but it is difficult to smelt because of its high TiO2 content and complex mineral phase. As early as June 1958, Mr. Chu-Phay Yap issued a written opinion on "urgent problems of iron ore bearing titanium in Panzhihua". Among them, the "urgent problem" is to break through some foreign scholars' judgment: "smelting this ore with blast furnace has little hope of success", and rely on domestic scientific research to overcome the problems of smelting vanadium-titanium magnetite ore with blast furnace in Panxi area. With the cooperation of related industries and research forces in China, it has been successfully broken through that difficult problem of smelting of vanadium-titanium magnetite ore with blast furnace in Panxi region, and further improved the level of smelting, reaching the world higher level in whole. In recent years, in addition to the continuous improvement of smelting level, the level of comprehensive utilization of that kind ore has also carried out a lot of original research work. Chongqing University is one of the earliest research institutes on comprehensive utilization of vanadium-titanium magnetite ore smelting. Over the years it has always took the vanadium-titanium magnetite smelting and its efficient utilization as the primary of metallurgical science research topic in the Chongqing University, and the unique processes of blast furnace smelting vanadium-titanium magnetite ore are studied systematically in the theory and technology, that has formed distinctive research features. In recent years, it has also been made that breakthroughs in theoretical and experimental research methods and made good progress in close cooperation with enterprises on smelting technology of high ratio vanadium-titanium magnetite ore in blast furnace, titanium extraction from titanium-containing blast furnace slag and titanium slag smelting technology in large electric furnace, as well as efficient and clean extraction technology of vanadium resources. This review gives a brief introduction on the clean metallurgy and efficient extraction research progress on Panxi vanadium-titanium magnetite ore in Chongqing University, to commemorate the contribution of Chu-Phay Yap and Yanxian Lin et al. scientific workers for the development and utilization of Panxi vanadium-titanium magnetite ore, and uphold their feet on the ground, as well as the innovation of scientific spirit. To promote the development of green and intelligent metallurgy and resource efficient utilization of vanadium-titanium magnetite ore in Panxi region under the carbon peaking and carbon neutrality goals.