In order to overcome the agglomeration problem of MnFe2O4 nanoparticles in practical applications, the high-gravity technology combining with the in?situ support of multiwalled carbon nanotubes (CNT) is proposed to prepare the CNT supported MnFe2O4 nano-material (MnFe2O4/CNT). The typical heavy metal pollution Pb(II) is selected as the research object to study the adsorption performance of MnFe2O4/CNT. First, the effects of different MnFe2O4 loads on the adsorption capacity toward Pb(II) are investigated, and the optimal MnFe2O4 load is determined to be 83.3wt%. The obtained MnFe2O4/CNT in the optimal MnFe2O4 load is charactered by XRD, SEM, N2 adsorption-desorption specific surface analyzer and VSM, and which exhibits an excellent magnetic property with a high saturation magnetization of 35.85 emu/g. Thus, the obtained MnFe2O4/CNT can be applied for the magnetic separation of pollutants in water. The results of adsorption experiments show that under the conditions of initial Pb(II) 300 mg/L and solution pH=6, the adsorption of Pb(II) on MnFe2O4/CNT in solution reached equilibrium after 180 min, and the adsorption equilibrium capacity is 80.7 mg/g, which is much higher than pure CNT (28.4 mg/g). The kinetic study demonstrates that the adsorption behavior of Pb(II) on MnFe2O4/CNT is most consistent with the Elvoch kinetic model,which suggests there exists a chemical adsorption in the adsorption mechanisms. Freundlich isotherm model describes well the adsorption process of Pb(II) on MnFe2O4/CNT, which represents a multilayer adsorption process on heterogeneous surfaces. In addition, the maximum adsorption capacity of MnFe2O4/CNT obtained from adsorption isotherm experiment is 106.2 mg/g, which displays excellent adsorption performance for Pb(II) and has a great potential in heavy metals removal in solution. According to the X-ray photoelectron spectroscopy analysis, it can be concluded that the adsorption mechanisms involve the complexation between Pb(II) and the hydroxyl groups on the surface of MnFe2O4.