Fluorite, as an important non-renewable non-metallic strategic mineral resource, has been valued by many countries. With the rapid development of science and technology and the national economy, its economic value and strategic position are increasingly prominent. In recent years, the fluorine chemical industry chain has been deepening, and the demand for fluorite resources has increased sharply. Due to the limited reserves of fluorite resources, uneven distribution of resources, trade protectionism, and anti-globalization forces, the global fluorine chemical industry is highly concentrated and highly monopolized. And there are great differences in the economic development, clean and efficient utilization of fluorite resources, and intensive processing technology in different countries and regions, which have a serious impact on the supply and demand of fluorite products and consumption patterns, and intensify the contradiction between fluorite resource reserves and the development of fluorite industry. In this review, the resource reserve, main industrial structure, the consumption structure of supply and demand, and clean utilization technology aspects in detail elaborated on the economic status and the strategic significance of fluorite resources. It is proposed to ensure the global strategic layout of fluorite resources by strengthening the reorganization of fluorite resources, clean and efficient utilization, deep processing technology and equipment research and development, high-end product manufacturing, etc. To further promote the development of the fluorite industry towards the direction of fine, complex, lightweight, environmental protection and energy-saving, recycling economy fluorite chemical products application field and high-tech industry application research and development, ensure the reserve and supply of fluorite resources, achieve the optimal allocation of global fluorite resources and the healthy and sustainable development of fluorite industry.