Antibiotics are commonly used drugs for the treatment of various infectious diseases in humans and animals, but the residual antibiotics released into the aquatic environment will threaten the ecological system. Therefore, it is important to explore efficient methods to remove antibiotics from the water environment. Photocatalytic ozonation technology has received extensive attention for its effective degradation and mineralization of persistent organic pollutants from the water matrix. In this work, Cu2O/TiO2 composite was prepared by the impregnation-chemical reduction method and was used as a catalyst for photocatalytic ozonation of ceftriaxone sodium (CRO) under visible light irradiation. The morphology, structure, and optical properties were investigated by X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscopy (TEM), nitrogen adsorption-desorption isotherms (BET) and ultraviolet-visible diffuse reflection (UV-Vis DRS). The effects of Cu2O/TiO2 ratio, Cu2O/TiO2 dosage, ozone concentration, initial concentration of ceftriaxone sodium, and initial pH value of the solution on visible-light-induced photocatalytic ozonation of ceftriaxone sodium were comprehensively investigated. The results showed that the doping of Cu2O on TiO2 increased the specific surface area and pore volume, reduced the energy gap, and improved the catalytic performance under visible light. The photocatalytic ozonation process had achieved a much higher removal rate of ceftriaxone sodium from an aqueous solution than the photocatalysis and ozonation processes. When the molar ratio of Cu2O:TiO2 was 0.2:1, the visible light irradiation time was 120 min, the initial pH value of the solution was 6.12, the concentration of ceftriaxone sodium was 10 mg/L, the dosage of Cu2O/TiO2 was 0.2 g/L and ozone concentration was 1.5 mg/L, the removal rates of ceftriaxone sodium and TOC were 81.05% and 52.16%, respectively, and the ozone utilization rate was 50.84%. The free radical capture experiments showed that photogenerated holes (h+) and superoxide radicals (?O2-) played a major role in the visible-light-induced photocatalytic ozonation of ceftriaxone sodium. Moreover, Cu2O/TiO2 exhibited satisfactory stability and reusability for 5 consecutive cycles. The findings of this study suggest that the photocatalytic ozonation process induced by visible light is a promising treatment technology for the abatement of ceftriaxone sodium pollution in an aqueous solution.