The problem of air pollution is becoming increasely serious, and it brings more and more problems to people's health. As one of the main sources of pollutants, choosing appropriate structure and operating parameters to reduce the pollutant emission of burner has become the research focus of many researchers. The combustion efficiency and emission of the burner are often determined by many factors. However, the existing studies mostly adopt local analysis, which only consider the impact of a single factor on the combustion efficiency and pollutant emission, and do not consider the impact of the correlation of various factors on the combustion performance of the burner. Due to the high cost of experiments, the optimization of multiple design parameters to improve the combustion performance of burner is still lack of systematic research. Taking a blast gas stove at 35 kW as the case study, the staged combustion model of the air flow inside the combustion chamber established is implemented by FLUENT to analyze the effects of different parameters and the model is verified by experimental data. In order to reduce the emission concentration of NOX and CO in the combustion chamber, a cyclone is installed on the original blast gas stove, and the combustion chamber height, air coefficient, the volume ratio of primary air to secondary air and the incident angle of secondary air are analyzed by numerical simulation, and the orthogonal experimental analysis is carried out finally. The results show that compared to the original parameters, the NOX concentration and the CO concentration discharged under the optimal situation decreased by 19.4 and 590 mg/m3, respectively. The study plays a role in the parameter optimization of the methane burner for reducing NOX and CO emission. It provides guidance for the design of low pollution combustion emission of burner.