To investigate the corrosion resistance of SiC refractory materials in the sodium smelting process of vanadium titanium magnetite, the wettability and interface behavior between vanadium titanium magnetite sodium smelting slag and SiC refractory substrate were studied in this research. In the process of the research, the sodium smelting slag of vanadium titanium magnetite and SiC refractory substrate were used as the experimental materials, a high-temperature wetting experimental device was used to investigate the influence of Na2O content changes on the wetting and interfacial behavior between the slag and the SiC refractory by the sessile drop method. The results indicated that as the Na2O content in the slag increased, the melting point of the slag significantly decreased, improving the wetting and spreading on the SiC substrate. At the same time and temperature, the contact angle between the molten slag and the SiC refractory substrate decreased with the increase of Na2O content. The interfacial energy between the refractory substrates was also reduced, leading to a tight bond between the slag and the SiC refractory substrate and easier wetting between the two phases. The formation of numerous sodium-containing low-melting compounds in the slag reduced its viscosity and enhanced its fluidity, thereby intensifying the diffusion of molecules or ions within the slag, which accelerated the oxidation of the SiC refractory material. As the Na2O content increased from 20.00wt% to 40.00wt%, the interaction between the slag and the substrate transitioned from a separated to an adhesive state, eventually forming a uniform reaction layer. The SiC refractory material exhibited good corrosion resistance to slag with 20.00wt% Na2O content, but this resistance gradually decreased as the Na2O content increased. These research results may provide some theoretical basis for the study of slag resistance in refractory materials during the sodium smelting process of vanadium titanium magnetite.