采取固体分散技术联合微囊技术制备兽用恩诺沙星复合掩味微囊，考察了其掩味效果；以其在模拟口腔液中的释放度、载药量和包封率为指标，利用单因素实验和正交实验优化制备工艺. 结果表明，复合微囊最优制备条件为：海藻酸钠溶液浓度15 g/L，滴加针头孔径1.0 mm，CaCl2浓度100 g/L，固化时间10 min. 该条件下所得复合微囊外观形态良好，载药量为20.3%，包封率为89.8%，平均粒径为273.67 μm；微囊在模拟口腔液中30 s的释放度小于猪对恩诺沙星的苦味阈值，有较好的掩味效果.

Solid dispersion was combined with microencapsulation technique to prepare composite taste-masking microcapsules of enrofloxacin for animals. Then, optimal preparation conditions of microcapsules were determined by a single factor and orthogonal experiments based on simulated oral release, drug loading capacity and encapsulation efficiency. Relevant properties of the composite microcapsules prepared with optimal methods were investigated. The results indicated that the optimized formulation conditions included 15 g/L sodium alginate solution, 1.0 mm aperture of adding needle, 100 g/L CaCl2 and 10 min curing time. The prepared composite microcapsules had a good appearance. The drug loading, encapsulation efficiency and average particle diameter of the prepared microcapsules were 20.3%, 89.8%, and 273.67 mm respectively. The release rate of microcapsule in the simulated oral fluid in 30 s was less than pigs' bitterness threshold to enroflloxacin. Therefore the composite microcapsules had a good taste masking effect.