以十六烷基三甲基溴化铵(CTAB)为改性剂改性钠基蒙脱土，基于均匀设计和多元非线性回归法考察了去离子水用量、CTAB用量、搅拌速度、搅拌温度和滴加时间对改性钠基蒙脱土片层间距的影响，表征了改性钠基蒙脱土的组成、结构和微观形貌. 结果表明，改性钠基蒙脱土的相容性提高，片层间距显著增加，各因素对改性钠基蒙脱土片层间距的影响程度为CTAB用量?搅拌温度?搅拌速度?去离子水用量?滴加时间. 优化的改性钠基蒙脱土方案为：去离子水用量358 g, CTAB用量0.47 g，搅拌速度2853 r/min，搅拌温度75.6℃，滴加时间128 min.

Modified Na-montmorillonite was prepared with cetyl trimethyl ammonium bromide (CTAB) as modifier. The effect of deionized water amount, CTAB amount, stirring speed, mixing temperature and drop in time on modified Na-montmorillonite interlamellar spacing was studied by uniform design and multivariate nonlinear regression. Composition, structure and microstructure of modified Na-montmorillonite were characterized. The results showed that compatibility of modified Na-montmorillonite increased, interlamellar spacing increased significantly. Primary and secondary sequence of factors on modified Na-montmorillonite interlamellar spacing is CTAB amount>mixing temperature>stirring speed>deionized water amount>drop in time. The optimization pconditions of modified Na-montmorillonite is deionized water amount 358 g, CTAB amount 0.47 g, stirring speed 2853 r/min, mixing temperature 75.6℃ and drop in time 128 min.