对云南某地难选氧化铜矿进行了SEM, XRD表征和铜物相分析，确立了硫化浮选的选矿工艺，进行了单因素实验，并通过响应曲面法优化浮选条件. 结果表明，响应曲面法优化精矿铜品位和回收率模型p值均小于0.05. 磨矿细度和磷酸乙二胺用量对铜精矿回收率有显著影响，磷酸乙二胺用量对铜精矿品位影响显著. 响应曲面法优化的最佳浮选条件为磨矿细度小于0.074 mm占86.07%、硫化钠用量2012.75 g/t、磷酸乙二胺用量132.19g/t，该条件下得到回收率79.007%、品位22.156%的铜精矿，通过浮选实验结果与响应曲面法优化结果基本一致. 根据优化的浮选条件进行浮选闭路流程实验，所得铜精矿含铜21.93%，回收率为76.23%.

The SEM, XRD characterization and copper content phase analysis were conducted on the refractory copper oxide at a certain place of Yunnan Province to ensure the mineral processing technology of sulfuration flotation. Besides, the single factor experiment was carried out and the flotation parameters were optimized through response surface methodology. The results showed that both of the grade of copper concentrate and the p value of recovery model were less than 0.05. The grinding fitness and the dosage of phosphoric acid ethylenediamine had a significant effect on the recovery of copper concentrate, and the dosage of phosphoric acid ethylenediamine had a significant effect on the grade of copper concentrate. The optimum flotation conditions of response surface methodology were the grinding fitness less than 0.074 mm accounting for 86.07%, the dosage of sodium sulphide 2012.75 g/t, the dosage of phosphoric acid ethylenediamine 132.19 g/t. Under these conditions, the copper concentrate recovery rate of 79.007% and grade of 22.156% were obtained. Basically, the results of flotation experiment and response surface methodology optimization were the same. In the closed-circuit flotation flowsheet under the optimized flotation conditions, the obtained copper concentrate contained 21.93% copper and the recovery rate was 76.23%.