基于可生物降解纳微颗粒的单剂免疫疫苗研究进展

杨美洋 王连艳 杨婷媛 阎雪莹

doi:10.12034/j.issn.1009-606X.217101

过程工程学报 >

2017 , Vol. 17 >Issue 5: 893 - 902

DOI: https://doi.org/10.12034/j.issn.1009-606X.217101

综述

基于可生物降解纳微颗粒的单剂免疫疫苗研究进展

杨美洋王连艳杨婷媛阎雪莹

展开

1. 黑龙江中医药大学药学院，黑龙江哈尔滨 150040；2. 中国科学院过程工程研究所生化工程国家重点实验室，北京 100190

收稿日期: 2017-01-03

修回日期: 2017-03-14

网络出版日期: 2017-10-10

收起

Progress of Single-dose Vaccine Using Nanoparticle-based Delivery System

Meiyang YANG Lianyan WANG Tingyuan YANG Xueying YAN?

Expand

1. College of Pharmacy, Heilongjiang University of Chinese Medicine, Haerbin, Heilongjiang 150040, China;
2. State Key Lab. Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

Received date: 2017-01-03

Revised date: 2017-03-14

Online published: 2017-10-10

Fold

摘要

接种疫苗是防控传染病的有效手段之一，多年来，人们一直致力于疫苗的研究与开发. 传统疫苗通常需多次免疫才能达到良好的免疫效果，偏远地区漏种情况严重，导致全球每年约有1亿儿童因不能按时接种疫苗而感染发病甚至死亡. 近年来，研究者们通过对缓、控释递送系统的研究，开发单剂疫苗，以提高疫苗接种覆盖率、有效防控传染病. 本工作主要对单剂疫苗的历史发展过程、基于可生物降解纳微颗粒的单剂疫苗的性质与调控、纳微颗粒单剂疫苗面临的挑战进行概述.

关键词： 单次免疫; 纳微颗粒; 免疫效应; 抗原释放调控

本文引用格式

杨美洋王连艳杨婷媛阎雪莹 . 基于可生物降解纳微颗粒的单剂免疫疫苗研究进展[J]. 过程工程学报, 2017 , 17(5) : 893 -902 . DOI: 10.12034/j.issn.1009-606X.217101

Abstract

Vaccination is one of the most effective methods for the prevention and treatment of infectious diseases. The scientists have focused on the research and development of vaccines for many years. Traditional vaccines usually require immunization for many times to achieve good immune response. Many people have not received timely immunization in remote area, which result in that there are over 100 million children each year around the world to be infected with disease or even death. Scientists have tried to develop novel single-dose vaccine basing on study of sustained and controlled release delivery systems in recent years. The successful development of single-dose vaccine will help to improve the vaccination rate and realize effective prevention and control of infectious diseases. This review elaborates the development process of single-dose vaccination, properties and regulation of single-dose vaccination based on biodegradable nanoparticles, potential strategies for the single-dose vaccination.

Key words： single-dose vaccine; nanoparticles; immune response; the regulation of antigen release

参考文献

[1] Kevin J.McHugh, Rohiverth Guarecuco, Robert Langer, Ana Jaklenec. Single-injection vaccines: Progress, challenges, and opportunities[J]. Journal of Controlled Release 2015,219: 596-609.
[2] Global routine vaccination coverage-2012 Centers for Disease Control and Prevention [R].MMWR Morb Mortal Wkly Rep 2013,62:858-861.
[3] M.T. Aguado, Future approaches to vaccine development: Single-dose vaccines using controlled-release delivery systems[J]. Vaccine 1993,11: 596-597.
[4] Jean-Pierre Y. Scheerlinck , Deanne L.V. Greenwood，Particulate delivery systems for animal vaccines[J].Methods 2006,40: 118–124.
[5] Rob Tierney, Toru Nakai, Christopher J. Parkins, Patrizia Caposio, Neil F. Fairweather,Dorothea Sesardic, Michael A. Jarvis，A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice[J].Vaccine 2012,30: 3047-3052.
[6] Alejandro Sanchez,?Rajesh K. Gupta,?Maria J. Alonso,?George R. Siber,?Robert Langer,Pulsed Controlled-Release System for Potential Use in Vaccine Delivery[J].Journal of Pharmaceutical Sciences 1996,85: 547-552.
[7] Jeffrey L. Cleland, Amy Lim, Lorena Barro′n, Eileen T. Duenas, Michael F. Powell，Development of a single-shot subunit vaccine for HIV-1: Part 4. Optimizing microencapsulation and pulsatile release of MN rgp120 from biodegradable microspheres[J].Journal of Controlled Release 1997,47: 135-150.
[8] J.L. Cleland, Single-administration vaccines: controlled-release technology to mimic repeated immunizations[J].Trends In Biotechnology 1999,17: 25-29.
[9] Li Feng, Xian Rong Qi, Xing Jun Zhou, Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres[J].Journal of Controlled Release 2006,112: 35-42.
[10] Xiaoling Zheng, Yongzhuo Huang, Alginate–Chitosan–PLGA Composite Microspheres Enabling Single-Shot Hepatitis B Vaccination[J]. The AAPS Journal 2010,12: 519-524.
[11] L.Shi; M.J.Caulfield; R.T. Chern; R.A. Wilson; G. Sanyal; D.B. Volkin, Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres[J].Journal of Pharmaceutical Sciences 2002,91: 1019-1035.
[12] G. Birrenbach,?P.P. Speiser, Polymerized Micelles and Their Use as Adjuvants in Immunology[J].Journal of Pharmaceutical Sciences 1976,65: 1763-1766.
[13] Ivan Preis,?Robert S. Langer, A single-step immunization by sustained antigen release[J]. Journal of Immunological Methods 1979,28: 193-197.
[14] P?l Johansen, Francisco Estevez, Rinaldo Zurbriggen, Hans P. Merkle, Reinhard Glück, Giampietro Corradin, Bruno Gander，Towards clinical testing of a single-administration tetanus vaccine based on PLA:PLGA microspheres[J].Vaccine 2001,19: 1047-1054.
[15] Fu-Shi Quan, Yeu-Chun Kim, Long-Term Protective Immunity from an Influenza Virus-Like Particle Vaccine Administered with a Microneedle Patch[J].Clinical and Vaccine Immunology 2013,20: 1433-1439.
[16] Lei Guo, Jianmin Chen, Yuqin Qiu, Suohui Zhang, Bai Xu, Yunhua Gao，Enhanced transcutaneous immunization via dissolving microneedle array loaded with liposome encapsulated antigen and adjuvant[J].International Journal of Pharmaceutics 2013,447: 22- 30.
[17] Pim Schipper, Koen van der Maaden, Stefan Romeijn, Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses[J].Journal of Controlled Release 2016,242: 141-147.
[18] J.M. Kemp, M. Kajihara, Continuous antigen delivery from controlled release implants induces significant and anamnestic immune responses[J].Vaccine 2002,20: 1089-1098.
[19] Mei-Chin Chen, Shih-Fang Huang, Kuan-Ying Lai, Ming-Hung Ling,Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination[J].Biomaterials 2013,34: 3077-3086.
[20] H.K. Makadia, S.J. Siegel, Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier[J].Polymers 2011,3: 1377-1397.
[21] Ivan Preis,?Robert S. Langer, A single-step immunization by sustained antigen release[J].Journal of Immunological Methods 1979,28: 193-197.
[22] Feng Wan, Mingshi Yang, Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying[J].International Journal of Pharmaceutics 2016,498: 82-95.
[23] Xiaoming Chen, Yuying Liu,Lianyan Wang,uan Liu,Weifeng Zhang,Bei Fan, Xiaowei Ma,Qipeng Yuan,Guanghui Ma,and Zhiguo Su，Enhanced Humoral and Cell-Mediated Immune Responses Generated by Cationic Polymer-Coated PLA Microspheres with Adsorbed HBsAg[J].Molecular Pharmaceutics 2014, 11: 1772-1784.
[24] Elena Mata, Manoli Igartua, Manuel E. Patarroyo, José Luis Pedraz, Rosa M. Hernández，Enhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginate[J].European Journal of Pharmaceutical Sciences 2011,44: 32-40.
[25] T. Kambayashi, T.M. Laufer, Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell? [J].Nature Review Immunology 2014,14: 719–730.
[26] Qi Liu, Xiaoming Chen, Jilei Jia, Weifeng Zhang, Tingyuan Yang, Lianyan Wang, and Guanghui Ma, pH-Responsive Poly(D,L-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response[J].ACS Nano 2015,9: 4925-4938.
[27] D. Lemoine, F. Wauters, S. Bouchend’homme, V. Prèat,Preparation and characterization of alginate microspheres containing a model antigen[J].International Journal of Pharmaceutics 1998,176: 9-19.
[28] D. Lemoine, F. Wauters, S. Bouchend’homme, V. Prèat,Preparation and characterization of alginate microspheres containing a model antigen[J].International Journal of Pharmaceutics 1998,176: 9-19.
[29] Liang Zhao, Arjun Seth, Nani Wibowo, Chun-Xia Zhao, Neena Mitter,Chengzhong Yu, Anton P.J. Middelberg, Nanoparticle vaccines[J].Vaccine 2014,32: 327-337.
[30] Bram Slütter, Peter Christiaan Soema, Zhi Ding, Rolf Verheul, Wim Hennink, Wim Jiskoot，Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen[J].Journal of Controlled Release 2010,143: 207-214.
[31] Weifeng Zhang, Lianyan Wang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia,Tingyuan Yang, Shaohui Qiu, Guanghui Ma，Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation [J]. Biomaterials 2014,35: 6086-6097.
[32] J.E. Rosas, J.L. Pedraz, R.M. Hernández, A.R. Gascón, M. Igartua,F. Guzmána, R. Rodr′?guez, J. Cortés, M.E. Patarroyo，Remarkably high antibody levels and protection against P. Falciparum malaria in Aotus monkeys after a single immunisation of SPf66 encapsulated in PLGA microspheres[J].Vaccine 2002,20: 1707-1710.
[33] Yogesh K. Katare, Amulya K. Panda，Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles[J].European Journal of Pharmaceutical Sciences 2006,28: 179-188.
[34] M.J. Alonso, S. Cohen, T.G. Park, R.K. Gupta, G.R. Siber, R. Langer, Determinants of release rate of tetanus vaccine from polyester microspheres[J].Archives of Pharmacal Research 1993,10: 945-953.
[35] M.J. Alonso, R.K. Gupta, C.Min, G.R. Siber, R. Langer, Biodegradable microspheres as controlled-release tetanus toxoid delivery systems[J].Vaccine 1994,12: 299-306.
[36] R.K. Gupta, J. Alroy, M.J. Alonso, R. Langer, G.R. Siber, Chronic local tissue reactions, long-term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polymers[J].Vaccine 1997,15: 1716-1723.
[37] Arvind K. Jain, Amit K. Goyal, Prem N. Gupta, Kapil Khatri, Neeraj Mishra, Abhinav Mehta,Sharad Mangal, Suresh P. Vyas，Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B[J].Journal of Controlled Release 2009,136: 161-169.
[38] René Rietscher, Matthias Schr?der, Julia Janke, Justyna Czaplewska, Michael Gottschaldt,Regina Scherlie, Andrea Hanefeld, Ulrich S. Schubert, Marc Schneider, Percy A. Knolle,Claus-Michael Lehr, Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity[J].European Journal of Pharmaceutics and Biopharmaceutics 2016,102: 20-31.
[39] F. Sarei, N.M. Dounighi, H. Zolfagharian, P. Khaki, S.M. Bidhendi, Alginate nanoparticles as a promising adjuvant and vaccine delivery system[J].Indian Journal of Pharmaceutical Sciences 2013,75: 442-449.
[40] Brendon Y. Chua, Toshiki Sekiya, Mohammad Al Kobaisi, Kirsty R. Short, David E. Mainwaring, David C. Jackson, A single dose biodegradable vaccine depot that induces persistently high levels of antibody over a year[J]. Biomaterials 2015,53: 50-57.
[41] Xiang S.D., Scholzen A., Minigo G., David C., Apostolopoulos V., Mottram P.L., Plebanski M., Pathogen recognition and development of particulate vaccines: does size matter? [J].Methods 2006,40: 1-9.
[42] Fumiaki Shima, Tomofumi Uto, Takami Akagi, Masanori Baba, Mitsuru Akashi, Size effect of amphiphilic poly(c-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo[J].Acta Biomaterialia 2013,9: 8894-8901.
[43] Douglas F. Nixon, Catarina Hioe, Pei-de Chen, Zuning Bian,Peter Kuebler, Ming-Lie Li, Howard Qiu, Xuan-Mao Li, Manmohan Singh, Julie Richardson, Paul McGee, Tim Zamb,Wayne Koff, Chang Yi Wang and Derek O’Hagan，Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity [J].Vaccine 1996,14: 1523-1530.
[44] Shiyu Yan, Wenyi Gu, Zhi Ping Xu，Re-considering how particle size and other properties of antigen–adjuvant complexes impact on the immune responses[J].Journal of Colloid and Interface Science 2013,395: 1-10.
[45] Li Feng, Xian Rong Qi, Xing Jun Zhou, Yoshie Maitani, Shi Cong Wang,Yang Jiang, Tsuneji Nagai, Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres[J].Journal of Controlled Release 2006,112: 35-42.
[46] Saravanakumar Arthanari, Ponnusamy Renukadevi, Vanitha Saravanakumar，Evaluation of lactose stabilized tetanus toxoid encapsulated into alginate, HPMC composite microspheres[J].Journal of Industrial and Engineering Chemistry 2014,20: 2018-2022 .
[47] Yogesh K. Katare, T. Muthukumaran, Amulya K. Panda, Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles[J].International Journal of Pharmaceutics 2005,30: 149-160.
[48] Vibhu Kanchan, Amulya K. Panda, Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response[J].Biomaterials 2007,28: 5344-5357.
[49] Andre FE., Overview of a 5-year clinical-experience with a yeast-derived hepatitis-B vaccine[J].Vaccine 1990,8: S74-8.
[50] Cutts FT, Franceschi S, Goldie S, Castellsague X, de Sanjose S, Garnett G, et al., Human papillomavirus and HPV vaccines: a review[J].Bulletin of the World Health Organization 2007,85: 719-26.
[51] Bin Park S., Hepatitis E vaccine debuts[J].Nature 2012,491: 21-2.
[52] Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, et al. Interbilayer crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses[J].Nature Materials 2011,10: 243-51.
[53] Gombotz W R,Wee S F, Protein release from alginate matrices[J].Advanced Drug Delivery Reviews.1998,31: 267-285.
[54] AJ. Baxendalea. van Hooff, L.G. Durrant, I. Spendlove, S.M. Howdle, H.M. Woods, M.J. Whitaker, O.R. Davies, A. Naylor, A.L. Lewis, L. Illum, Single shot tetanus vaccine manufactured by a supercritical fluid encapsulation technology[J].International Journal of Pharmaceutics 2011,413:147-154.
[55] K.D. Newman, P. Elamanchili, G.S. Kwon, J. Samuel, Uptake of poly(D, L-lactic-coglycolic acid) microspheres by antigen-presenting cells in vivo[J].Journal of Biomedical Materials Research Part A 2002, 60: 480-486.
[56] M. Peyre, R. Fleck, D. Hockley, B. Gander, D. Sesardic, In vivo uptake of an experimental microencapsulated diphtheria vaccine following sub-cutaneous immunisation[J].Vaccine 2004,22: 2430-2437.
[57] M. Sola-Penna, J.R. Meyer-Fernandes, Stabilization against thermal inactivation promoted by sugars on enzyme structure and function: why is trehalose more effective than other sugars?[J].Archives of Biochemistry and Biophysics 1998,360: 10-14.
[58] S. Singh, A. Singh, M.A. Aziz, S.M.Waheed, R. Bhat, R. Bhatnagar, Thermal inactivation of protective antigen of Bacillus anthracis and its prevention by polyolosmolytes[J].Biochemical and Biophysical Research Communications 2004,322: 1029-1037.
[59] Karina R. Vega-Villa, Jody K. Takemoto, Jaime A. Yá?ez, Connie M. Remsberg, M. Laird Forrest, Neal M. Davies, Clinical toxicities of nanocarrier systems[J].Advanced Drug Delivery Reviews 2008,60: 929-938.
[60] Liang Zhao, Arjun Setha, Nani Wibowo, Chun-Xia Zhao, Neena Mitter, Chengzhong Yu, Anton P.J. Middelberg, Nanoparticle vaccines[J].Vaccine 2014,32: 327-337.
[61] Manmohan Singh, Xuan-Mao Li, J.P. McGee, Tim Zamb, Wayne Koff, Chang Yi Wang and D.T. O’Hagan, Controlled release microparticles as a single dose hepatitis B vaccine:evaluation of immunogenicity in mice[J].Vaccine 1997,15: 475-481.

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract

参考文献