Ethylene oxide (EO) is an important intermediate in organic synthesis with a wide range of uses. The special physicochemical properties of ethylene oxide were analyzed for the safety problems of production, storage, transportation and use. EO had a very actively chemical properties, such as the molecule ring was easily opened which would release lots of heat. It is flammable and explosive as that the explosion limit was from 3% to 100% in the air, and the ignition was minimal only 0.06 mJ. The safety operation designs and matters needing attention had been analyzed and discussed along with its special physicochemical properties, reaction characters, easy to self-polymerize, disintegrate and decompose, etc., which was aimed to solve the security problems existing in chemical production processes. The specific suggestions were put forward to improve safety and reliability in it production, transportation and producing, including related device layout design, safety temperature and pressure design, equipment safety and emergency treatment design, etc., and it would lead to reduce the related accidents.
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