采用快速膜乳化技术，以大豆油为油相、葡萄糖为固化剂，制备均一载硫酸亚铁明胶微球，考察了制备参数对明胶微球形貌和均一性的影响. 结果表明，优化的制备参数为明胶溶液浓度0.200 g/mL、乳化剂浓度0.07 g/mL、初乳均质转速10000 r/min、固化反应时间20 min. 在该条件下制备了球形圆整、平均粒径为50 μm的均一载FeSO4明胶微球，FeSO4包埋率达44.12%，Fe2+含量为60.8%.

Ferrous sulfate-loaded gelatin microspheres were prepared by premix membrane emulsification, using soybean oil with food grade as oil phase and glucose as solidification agent, the effects of preparation conditions on microspheres morphology and size distribution examined, and the optimal conditions of gelatin microspheres obtained. The results showed that under the optimal concentrations of gelatin solution and emulsifier at 0.200 and 0.07 g/mL respectively, homogenizing rate 10000 r/min, and solidification time 20 min, the gelatin microspheres loading ferrous sulfate were successfully prepared. The microspheres were spherical and uniform in size, and their mean size was 50 μm and encapsulation efficiency of ferrous sulfate 44.12%, containing 60.8% ferrous ion.